Worms are important decomposers in soil and are great for fishing, but in humans, the slimy wrigglers spell trouble. Hookworms, whipworms, Ascaris, Guinea worms and trichina worms are just a few parasitic nematodes that infect some 2 billion people.
Now, researchers have discovered a class of small molecules that all nematodes use to signal such processes as growing, developing, mating and moving toward or away from an area. The finding could lead to prevention and treatments for worm parasites that widely infect humans, animals and crops.
"All of these nematodes speak the same chemical language," through the use of compounds called ascarosides, said study co-author Frank Schroeder, a research scientist at the Boyce Thompson Institute (BTI) for Plant Research and adjunct assistant professor in Cornell’s Department of Chemistry and Chemical Biology.
The study, published online April 12 in the journal Current Biology, was led by Stephan von Reuss, a postdoctoral associate in Schroeder’s lab, and Andrea Choe, a postdoctoral scholar in the lab of co-author Paul Sternberg, a biologist at the California Institute of Technology.
Since nematodes are the only known organisms to use ascarosides, "we don’t have to be afraid of interfering with similar biochemistry in animals, plants or humans," Schroeder said, as researchers seek to identify species-specific ascaroside molecules that may enable novel approaches to deter or disrupt the survival or reproduction of parasitic worms.